Infrared nerve stimulation

http://www.bioopticsworld.com/articles/print/volume-1/issue-6/features/neurological-treatment/infrared-nerve-stimulation-hearing-by-light.html

 

Infrared charging https://www.facebook.com/exploristscience/videos/1261899520574908/

 

Fisher Wallace stimulator approved by the FDA to treat depression, anxiety and insomnia

https://www.fisherwallace.com/pages/how-it-works

 

(from a post by Robert Duncan)

 

Information from the company:

“The device uses a patented waveform of three frequencies: 15 Hz, 500 Hz, and 15,000 Hz. The amperage that the device uses is 1-4 mA (level 1-4). The device uses a bipolar square wave frequency.” Unfortunately, we do not have the duty cycle.

 

Voltage: 0-40 Volts. 

 

 

I was interested in understanding the conditions of electrostimulation. Here are some excerpts from different articles on the scientific evidence page (instruments from different companies).

 

Electrosleep: a double-blind clinical study.

The Neurotone 101 was used. It is a transistorized, battery-powered frequency source that generates a gated sine wave burst of current with no direct current bias. Burst rate was 100 hertz/second with a burst width of 2 msec. This current was used to treat the alternating current treatment group. For the direct current treatment group the output was rectified and filtered to form positive square wave pulses of the same width and frequency.

 

Cranial electrotherapy stimulation for the treatment of depression.

The original FDA grandfathered CES device, the Neurotone 101, pulsed at 50 and 100 Hz, biphasic, on a 20% duty cycle. There was no dc bias.

 

Cranial electrotherapy stimulation as a treatment for anxiety in chemically dependent persons.

Four Neurotone 101 units were used for the CES treatments. These promised a series of low intensity, sinusoidal electric impulses at 100 pulses/sec on a 20% duty cycle with current variable from 0.0 to 1.0mA.

 

 

Effects of transcrerebral electrotherapy (electrosleep) on state anxiety according to suggestibility levels.

The apparatus was a Neurotone 101 manufactured by Neuro-Systems,Inc. of Garland, Texas. It is a portable, battery-operated, solid-state unit which generates a gated sine wave burst of current with no dc bias. Burst rate was 100 Hz, with a width of 2 msec.

 

Electrosleep therapy: a controlled study of its effects in anxiety neurosis.

A Neurotone l0l (9) set to give a 20 V unidirectional square wave of 2 msec duration at a frequency of I00 Hz. with a maximum current of 1.5 mA was used.

 

 

Cranial electrotherapy stimulation (CES): a safe and effective low cost means of anxiety control in a dental practice.

The AlphaStim is a microcurrent stimulator that produces a modified biphasic square waveform of varying pulse widths, at a 50 percent duty cycle.(...). It was set at 0.5 Hz frequency, which produces a variable pulse width in this device. The current was standardized below the normal recommended usage of "maximum comfortable level" to 200 uA because at that low level, the output is generally subsensory, allowing for doubleblind (...)

 

The Alpha-Stim SCS provides cranial electrical stimulation by generating bipolar, asymmetric, rectangular waves with a frequency of 0.5 Hz and a current intensity that can be adjusted continuously to provide between 10 uA and 500 uA.

 

 

The administration of transcranial electric treatment for affective disturbances therapy in alcoholic patients.

Combination of constant electric current with a pulse current of square impulses of 70-80 Hz and 4 - 7 mA, i.e., in a regime activating endorphinergic brain systems

 

 

Efficiency of transcranial electrostimulation on anxiety and insomnia symptoms during a washout period in depressed patients. A double-blind study.

(Diastym)

An anode was placed on each eyelid and a cathode applied to the mastoids. Such a disposition allows rather low impedance levels (500-100 [l for the anode-eyelid contact and 1500-2000 [l for the cathode-mastoid contact). Rectangular monophasic pulses of 0.7 msec duration were delivered at a frequency of 350 Hz, the intensity of the stimulation being adjusted to just below the cutaneous perception threshold, which corresponded to approximately 1-1.2 mA. 

 

Cranial Electrotherapy Stimulation (CES) in the treatment of anxiety and other stress-related disorders: a review of controlled clinical trials.

TABLE WITH CONDITIONS

 

 

PAIN RESEARCH

Pain reduction using transcranial electrostimulation: a double blind "active placebo" controlled trial.

Pulse Mazor Instrument’s Transcranial ElectroStimulator (TCES) equipment, Pulsatilla 1000 (Pulse Mazor Instruments, Rehovot, Israel).

A paramedic (other than the evaluating doctor) administered 8 30-min treatment sessions, on 8 consecutive weekdays. The instrument was in mode 3, which is asymmetrical, biphasic shape for zero net charge, 77 Hz of frequency, and 3.3 millisec of pulse width (± 5%), in a dual channel current manner. This pulse shape prevents charge accumulation in the tissue. Patients receiving placebo were treated with a 50 Hz signal with maximal current of 0.75 mA (as described previously (6)).

 

 

 

Creating action potentials/neural impulses by infrared pulse laser, focused pulse microwaves (and/or maser pulse beam), focused pulse ultrasound

 

Excerpts from this study:

facebook post


« Action potentials or nerve impulses are not created only by electrical stimulation. It has been demonstrated that nerve stimulation by low-intensity pulsed infrared light is possible (2). In this case, action potentials are created by absorption of infrared energy. In other words, this absorption increases the temperature creating an action potential. It has been calculated that the temperature increase of 6°C (from baseline temperature) is the bio-physical mechanism responsible for stimulation of sciatic nerve of rats and frogs (2). This optical stimulation in vivo exhibits advantages over standard electrical means by providing high spatial selectivity, contact-free and artifact-free stimulation for peripheral nerves (3). »

 

« Another possible electromagnetic source for future noninvasive brain stimulation are microwaves. Currently, focused microwaves have been employed for thermal ablation of tumours (4). However, the brain absorption mechanism of microwave energy, counting for focused microwave brain stimulation is expected to be mediated by similar thermal effect present in infrared laser stimulation. In addition, future techniques concerning focusing microwave beam pulses, that is microwave amplification through stimulated emission of radiation (maser) pulses can play a major role in localized human deep brain stimulation, eliciting an action potential while increasing the baseline temperature. »

 

« A mechanical energy source such as high frequency sound is another possibility for noninvasive deep brain stimulation. Currently, focused ultrasound is combined with MRI to perform thermal ablation of tumours (5). However, it has been recently shown that focused pulse ultrasound excites mouse brain hippocampus area in vitro responses (6). »

 

Reference 2 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1965456/

Excerpts :
« Temperature can affect action potential propagation in three ways: 1), the Nernst equilibrium potentials are inversely proportional to the absolute temperature; 2), the conductance of an open ion channel is dependent on a common temperature factor governing the rate for channel induction called a Q10; and 3), a change in temperature changes the amplitude and duration of the potential (41). One hypothesis for the physiological mechanism for optical stimulation involves sodium channel activation based on a local increase in the conductance as the channel transitions to the open state resulting from a temperature increase. »

 

« A second potential hypothesis is the activation of heat-sensitive channels, where the gating mechanism is markedly different from the other channel types: voltage-gated, ligand-gated, and mechanosensitive ion channels. »

 

 

 

 

 

 

 

Posted 2016-07-25 

Transcranial Laser Stimulation

 

 

Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms

tweet by Tim Watson

 

 

 

Posted 2016-07-19

Neuroscientists @BIDMChealth, a major @harvardmed teaching hospital, warn against DIY brain stimulation

Link

 

https://twitter.com/infobookcom/status/755364009499561984

 

 

 

 

 

 

 

Posted 2016-05-10

Can't solve riddle? Pass electric current in brain: 40% of non-solvers will solve it

A sort of brain electro-shock by TMS

Article by Scientific American :""Does Zapping Your Brain Increase Performance?"

"The evidence for neurostimulation is decidedly mixed" 

Link (to article)

 

 

 

 

TMS (Transcranial Magnetic Stimulation) against Depression:

Accessing electrically the mood circuits to modulate neurotransmitter release

 

A therapy approved by the US Food and Drug Administration (FDA)

 

Background from the US National Institute of Mental Health (NIMH)

http://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies.shtml

"In October 2008, rTMS was approved for use by the FDA as a treatment for major depression for patients who have not responded to at least one antidepressant medication."

 

Physics Principle: Electromagnetic Induction

A changing magnetic field induces electricity in a conductor: The phenomenon of Electromagnetic Induction

 

A changing flow of magnetism (represented by magnetic lines) as magnet is being moved towards coiled wire. Electricity is detected by the instrument. 

https://en.wikipedia.org/wiki/Electromagnetic_induction

Generalization: a time-varying magnetic field induces electricity in a conductor

(Note that in the figure above representing moving the magnet, the magnetic field changes with time - different position of magnetic lines as times goes by)

 

 

https://en.wikipedia.org/wiki/Transcranial_magnetic_stimulation

 

Transcranial magnetic stimulation.jpg

During a TMS procedure, a magnetic field generator, or "coil" is placed near the head of the person receiving the treatment.[1]:3 The coil produces small electric currents in the region of the brain just under the coil via electromagnetic induction.

 

 

 

What happens if you deliver electicity to cells? If you change the voltage of neurons you can induce the release of neurotransmitters.

 

https://en.wikipedia.org/wiki/Depolarization

Depolarization in the context of biology refers to the sudden change within a cell during which the cell undergoes a dramatic electrical change. Most cells, especially those that compose the tissues of highly organized animals, typically maintain an internal environment that is negatively charged compared to the cell's surrounding environment. This difference in charge is known as the membrane potential of the cell. In the process of depolarization, the negative internal charge of the cell becomes positive for a very brief period of time. This shift from a negative to a positive internal cellular environment allows for the transmission of electrical impulses both within a cell and, in certain instances, between cells.

 

https://en.wikipedia.org/wiki/Chemical_synapse

"Illustration of the major elements in chemical synaptic transmission. An electrochemical wave called an action potential travels along the axon of aneuron. When the action potential reaches the presynaptic terminal, it provokes the release of a small quantity of neurotransmitter molecules, which bind to chemical receptor molecules located in the membrane of another neuron, the postsynaptic neuron, on the opposite side of the synaptic cleft."

 

 

Information

http://www.neuronetics.com/products-services/how/

 

Below are 6 slides from the presentation on NeuroStar TMS that has been created by the the Pillsen Wellness Center (Chigago, IL, USA) and that is available at the link http://www.slideshare.net/pilsenwellness/tms-therapy-at-pilsen-wellness-center 

 

 

Depressed Brain: Depressed brain activity in many areas - Hyperactivity in some

Slide 16 - Pilsen WellnessCenter

 

 

 

 

Neurotransmitters flowing in circuits

Slide 18 - Pilsen WellnessCenter

 

 

 

 

Symptoms

Slide 19 - Pilsen WellnessCenter

 

 

 

 

Antidepressant drugs

Slide 20 - Pilsen WellnessCenter

 

 

 

 

Change of membrane voltage leads to secretion of neurotransmitters

 

 

 

 

TMS releases neurotransmitters in the brain

 

 

http://neurostar.com/neurostar-tms-depression-treatment/how-neurostar-tms-works/

 

Interesting video by Neurostar (FDA-approved TMS approach)

Healthy brain

 

 

 

 

Depressed brain

 

 

 

Release of neurotransmitters

 

 

 

Patient Test. Identification of the patient's motor threshold

Determination of the magnetic field strength that results in an an observable motor response, such as the movement of the thumb. Measured in SMT units.

FDA Link SMT Unit: So that measurement of stimulator magnetic field output may be standardized, the SMT unit is suggested. 1.0 SMT is the output setting of a rTMS device that corresponds to an induced electric field of 130V/m at a point located at the fixed distance of the target along the central axis of the coil from the surface of the scalp into the cortex.

 

 

 

 

 

 

 

 

http://www2.kenes.com/wcn/scientific/Documents/TC33_Rossini_Hall%20I_Tue%20[Read-Only].pdf

 

"Transcranial magnetic stimulation (TMS) is performed by placing on the skull, above the motor cortex, an electromagnetic coil that supplies an alternating current generated by a capacitor. This produces a time variable magnetic field of duration of 100-200 μs. The intensity of the generated magnetic field is about 2 tesla (value corresponding approximately to 40,000 times the Earth's magnetic field or, roughly, to the magnetic field used in magnetic resonance imaging). The variable magnetic field induces a current flow in the nervous tissue sufficient to produce a neuronal depolarization.

 

 

https://en.wikipedia.org/wiki/Tesla_(unit)

 

  • 31.869 µT (3.2 × 10−5 T) – strength of Earth's magnetic field at 0° latitude, 0° longitude
  • 5 mT – the strength of a typical refrigerator magnet
  • 1 T to 2.4 T – coil gap of a typical loudspeaker magnet
  • 1.5 T to 3 T – strength of medical magnetic resonance imaging systems in practice, experimentally up to 17 T[11]

 

 

Scientific article

Guidelines Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)

Clinical Neurophysiology 125 (2014) 2150–2206

pdf link

 

 

Transcranial Direct Current Stimulation

 

 

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