Alteration of brain function with interferential electric fields - Steerably probing functionality of different brain areas

 

http://www.cell.com/cell/fulltext/S0092-8674(17)30584-6

 

"(...) If two such electric fields are applied at high frequencies that differ by a small amount, which corresponds to a low frequency that neurons can follow, neurons in the brain may be able to demodulate and follow the envelope modulation that results from the temporal interference between these two applied fields, and which oscillates at the difference frequency."

 

"We found that interferential stimulation with two sinusoids at 2.01 kHz and 2 kHz, resulting in a ΔEq envelope frequency of 10 Hz, was able to recruit neurons to fire at 10 Hz (Figure 1D), as efficaciously as direct 10 Hz stimulation (Figure 1E) that would be expected to broadly affect neural activity (Miranda et al., 2013)."

 

"If the amplitude of the envelope modulation reaches a maximum at a site deep in the brain, it might be possible to drive deep-lying neurons without recruiting overlying ones. We here test this concept, which we call temporal interference (TI) stimulation, by using computational modeling and phantom measurements, as well as electrophysiological measurements in vivo.

 

"We demonstrate the ability of temporal interference (TI) stimulation to mediate activation of hippocampal neurons without recruiting overlying cortical neurons and steerably probe motor cortex functionality without physically moving electrodes by altering the current magnitudes delivered to a fixed set of electrodes."

 

 

 

 

Reconditioning the brain to overcome fear

 

Link

Researchers have discovered a way to remove specific fears from the brain, using a combination of artificial intelligence and brain scanning technology.

 

 

 

 

Restoring Faulty Decision Making

Induction of "incorrect decision" via cocaine and restauration by imposing "correct decision" neural code

 

An example provided by the following study will be presented briefly:

 

Facilitation and restoration of cognitive function in primate prefrontal cortex by a neuroprosthesis that utilizes minicolumn-specific neural firing.

Hampson RE, Gerhardt GA, Marmarelis V, Song D, Opris I, Santos L, Berger TW, Deadwyler SA.

J Neural Eng. 2012 Oct;9(5):056012. Epub 2012 Sep 13. 

PMID: 22976769 Free PMC Article

 

Let us consider the use case of restauring faulty decision making related to a visual stimulus.

 

Choose this experimental setting: Monkey that matches image to correct image gets sweet reward.

 

Which neurons do decision making from visual representations? This information is known: L2 neurons. 

 

We would need to decipher the neural code they generate.

 

What are they connected to? L5 neurons.

 

Then proceed by deciphering the neural code of L2 and L5.

 

Start by measuring their neural signals. They are 1350 μm apart so you need to have two electrodes at this distance. You build an electrode array that fits that.

 

You obtain recordings for correct decision and incorrect decision. How can you induce an incorrect decision? By using a drug like cocaine. You then analyse the recordings and you extract patterns using a non-linear dynamic model (MIMO). You determine the code for correct decision and code for incorrect decision. Having identified these, when you detect incorrect decision code you apply the code associated with correct decision making.

 

In the image below, we have a neural column (blue neuron on top of red). We measure the blue (L2) and we detect that it has a weak code. We therefore proceed by imposing strong code on the red (L5). In a way we are modifying the output of L2.

 

Figure 1: Excerpt from figure 8 of the publication demonstrating detection using MIMO model of weak L2/3 code following cocaine exposure. Output of MIMO model is then utilized to stimulate L5 with a “strong code” L5 pattern associated with correct decision.

 

Just to have an idea of what neural code looks like, here is an image which shows L2 above (weak) and L5 below (strong) after imposing the model prediction.

 

 

Figure 2: Excerpt of figure 4 of the publication demonstrating recording of L2 representing "weak code" according to analysis with MIMO model and imposition of "strong code" to L5.

 

 

 

In general, let us assume that you record neural signals with electrodes. You will then need a pattern extractor, and therefore a neural network model for this. It is mentioned in the literature that “A number of neural network (NN) models have been developed for pattern recognition and classification since mid-1980s. They include the backpropagation NN, counterpropagation NN, adaptive conjugate gradient neural network algorithm, recurrent NN, radial basis function NN (RBNN), wavelet NN, spiking NN, neural dynamics models, neuro-genetic models, and the probabilistic neural network (PNN) (Specht, 1990). PNN is often used for classification purposes (Adeli and Panakkat, 2009).”

 

 

 

In this case, the authors used a "Multi-input/multi-output (MIMO) nonlinear dynamic model."

 

 

 

"Brain chips: Human trials on futuristic implants to enhance memory and treat Alzheimer's begin" via IBT

Link

Scientists from the same group as above are performing clinical trials of their technology on humans.

 

 

 

Introduction to Neuronal Networks

Here is an interesting link that provides an introduction to Neurons and Neuronal Networks

 

 

 

A brief history of neuromorphic engineering via @HumanBrainProj @FurberSteve

doi.org/bpcp

 

Excerpt:

A feature of the biological brain is that while communication uses digital techniques for fast signalling over all but the shortest distances, all of the processing in neurons

and synapses uses much more efficient analogue chemical techniques [3].

 

 

 

2016-08-10: Human Brain Project Neurorobotics Platform release

 

HBP Neurorobotics platform EU Review release: http://youtu.be/ee0iZaiQjLU?a  via @YouTube

 

Capture from above video:

 

 

 

Neural Codes